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Domenica Altavilla Selected Research

Polydeoxyribonucleotides

4/2022Beneficial Effects of Polydeoxyribonucleotide (PDRN) in an In Vitro Model of Fuchs Endothelial Corneal Dystrophy.
10/2021Polydeoxyribonucleotide: A Promising Biological Platform to Accelerate Impaired Skin Wound Healing.
7/2021Targeting Adenosine Receptor by Polydeoxyribonucleotide: An Effective Therapeutic Strategy to Induce White-to-Brown Adipose Differentiation and to Curb Obesity.
2/2020PDRN, a Bioactive Natural Compound, Ameliorates Imiquimod-Induced Psoriasis through NF-κB Pathway Inhibition and Wnt/β-Catenin Signaling Modulation.
1/2016Adenosine Receptor Stimulation by Polydeoxyribonucleotide Improves Tissue Repair and Symptomology in Experimental Colitis.
1/2015Role of Inhibitors of Apoptosis Proteins in Testicular Function and Male Fertility: Effects of Polydeoxyribonucleotide Administration in Experimental Varicocele.
1/2012Polydeoxyribonucleotide administration improves the intra-testicular vascularization in rat experimental varicocele.
11/2011Polydeoxyribonucleotide reduces cytokine production and the severity of collagen-induced arthritis by stimulation of adenosine A(₂A) receptor.
3/2011Activation of adenosine A2A receptors by polydeoxyribonucleotide increases vascular endothelial growth factor and protects against testicular damage induced by experimental varicocele in rats.
10/2009Polydeoxyribonucleotide (PDRN): a safe approach to induce therapeutic angiogenesis in peripheral artery occlusive disease and in diabetic foot ulcers.
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Domenica Altavilla Research Topics

Disease

22Wounds and Injuries (Trauma)
10/2021 - 04/2003
14Inflammation (Inflammations)
04/2022 - 01/2003
14Ischemia
10/2021 - 10/2004
13Reperfusion Injury
01/2016 - 08/2003
12Shock
04/2012 - 01/2002
9Necrosis
03/2017 - 01/2003
9Ischemic Stroke
04/2012 - 03/2006
6Neoplasms (Cancer)
11/2021 - 04/2004
6Brain Ischemia (Cerebral Ischemia)
04/2012 - 03/2006
5Systemic Scleroderma (Systemic Sclerosis)
01/2018 - 08/2013
5Metabolic Syndrome (Dysmetabolic Syndrome X)
06/2017 - 03/2009
5Osteoporosis
02/2017 - 10/2002
5Insulin Resistance
01/2017 - 03/2005
5Burns
01/2015 - 04/2003
5Pancreatitis
11/2014 - 04/2003
5Myocardial Ischemia (Ischemic Heart Diseases)
04/2012 - 08/2003
5Stroke (Strokes)
11/2011 - 05/2006
5Hypotension (Low Blood Pressure)
07/2008 - 01/2002
4Hypoxia (Hypoxemia)
10/2021 - 10/2009
4Traumatic Brain Injuries (Traumatic Brain Injury)
08/2020 - 03/2012
4Varicocele
05/2020 - 03/2011
4Arthritis (Polyarthritis)
01/2019 - 01/2003
4Edema (Dropsy)
01/2018 - 01/2003
4Pulmonary Fibrosis (Fibrosing Alveolitis)
01/2018 - 08/2013
4Bone Resorption
01/2017 - 10/2002
4Sepsis (Septicemia)
01/2015 - 02/2012
4Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker)
12/2009 - 03/2006
4Spermatic Cord Torsion (Testicular Torsion)
04/2009 - 10/2004
3Stomatitis
02/2022 - 06/2020
3Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
11/2021 - 10/2016
3Multiple Myeloma
11/2021 - 10/2016
3Colitis
10/2020 - 01/2016
3Ulcer
01/2018 - 10/2009
3Fibrosis (Cirrhosis)
01/2018 - 08/2013
3Prostatic Hyperplasia (Benign Prostatic Hyperplasia)
03/2017 - 10/2011
3Brain Injuries (Brain Injury)
06/2015 - 01/2004
3Cardiovascular Diseases (Cardiovascular Disease)
08/2013 - 04/2004

Drug/Important Bio-Agent (IBA)

30Proteins (Proteins, Gene)FDA Link
01/2018 - 01/2002
21Messenger RNA (mRNA)IBA
05/2020 - 01/2002
20Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
02/2018 - 04/2003
19Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
11/2015 - 01/2002
18salicylhydroxamic acid (SHAM)IBA
05/2020 - 01/2002
16GenisteinIBA
06/2017 - 10/2002
16NF-kappa B (NF-kB)IBA
11/2010 - 01/2002
14MelanocortinsIBA
03/2014 - 08/2004
11PolydeoxyribonucleotidesIBA
04/2022 - 05/2008
9flavocoxidIBA
02/2022 - 12/2009
9AntioxidantsIBA
02/2022 - 06/2002
9Phosphotransferases (Kinase)IBA
01/2018 - 02/2005
8Peptides (Polypeptides)IBA
04/2012 - 08/2004
7Purinergic P1 Receptors (Adenosine Receptor)IBA
07/2021 - 10/2009
7InflammasomesIBA
08/2020 - 05/2014
7Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA
11/2017 - 04/2003
7Mitogen-Activated Protein KinasesIBA
11/2014 - 02/2005
6Adenosine A2A Receptor (Adenosine A2A Receptors)IBA
04/2022 - 03/2011
6Nitric Oxide (Nitrogen Monoxide)FDA Link
11/2017 - 07/2002
6Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA
01/2016 - 07/2002
6Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA
11/2015 - 11/2005
6Melanocyte-Stimulating Hormones (MSH)IBA
03/2014 - 01/2010
6NF-KappaB Inhibitor alphaIBA
07/2008 - 01/2002
5caryophylleneIBA
11/2021 - 01/2019
5Reactive Oxygen Species (Oxygen Radicals)IBA
10/2021 - 01/2011
5LipopolysaccharidesIBA
01/2019 - 06/2002
5NitritesIBA
02/2018 - 07/2002
5IsoflavonesIBA
06/2017 - 10/2002
4Biological ProductsIBA
11/2021 - 06/2016
4CateninsIBA
11/2021 - 01/2018
4CollagenIBA
10/2021 - 08/2004
4CytokinesIBA
10/2021 - 01/2002
4Malondialdehyde (Propanedial)IBA
05/2020 - 11/2015
4LycopeneIBA
05/2020 - 10/2011
4NitratesIBA
02/2018 - 07/2002
4Glucose (Dextrose)FDA LinkGeneric
10/2012 - 03/2005
4Adrenocorticotropic Hormone (ACTH)FDA Link
04/2012 - 08/2004
4Neuroprotective AgentsIBA
03/2012 - 03/2006
4Interleukin-6 (Interleukin 6)IBA
03/2012 - 04/2009
4Hormones (Hormone)IBA
10/2011 - 04/2004
4CeruletideIBA
05/2011 - 04/2003
4alpha-MSHIBA
08/2009 - 03/2006
4Mitogen-Activated Protein Kinase 3IBA
02/2009 - 10/2004
4OsteoprotegerinIBA
05/2008 - 03/2005
4JNK Mitogen-Activated Protein KinasesIBA
07/2007 - 10/2004
4Vitamin EFDA LinkGeneric
10/2005 - 06/2002
3Cannabinoid Receptors (Cannabinoid Receptor)IBA
11/2021 - 01/2019
3dinitrobenzenesulfonic acidIBA
10/2020 - 01/2016
3Hyaluronic Acid (Hyaluronan)IBA
10/2020 - 01/2003
32,4-dinitrofluorobenzene sulfonic acidIBA
10/2020 - 01/2016
3Interleukin-18 (Interleukin 18)IBA
08/2020 - 11/2010
3Biomarkers (Surrogate Marker)IBA
08/2020 - 08/2013
3Testosterone (Sustanon)FDA Link
05/2020 - 10/2011
3Simvastatin (Zocor)FDA LinkGeneric
01/2016 - 02/2008
3DystrophinIBA
09/2015 - 03/2006
33,7-dimethyl-1-propargylxanthineIBA
01/2015 - 11/2011
3EnzymesIBA
11/2014 - 04/2003
3Fibrinogen (Factor I)FDA Link
10/2012 - 03/2005
3Insulin (Novolin)FDA Link
10/2012 - 03/2005
3Interleukin-10 (Interleukin 10)IBA
03/2012 - 02/2011

Therapy/Procedure

4Injections
09/2013 - 10/2004
3Ligation
01/2015 - 04/2012
3Punctures
01/2015 - 04/2012